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frozen human peripheral blood mononuclear cells (pbmcs)  (STEMCELL Technologies Inc)

 
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    STEMCELL Technologies Inc frozen human peripheral blood mononuclear cells (pbmcs)
    Frozen Human Peripheral Blood Mononuclear Cells (Pbmcs), supplied by STEMCELL Technologies Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/frozen human peripheral blood mononuclear cells (pbmcs)/product/STEMCELL Technologies Inc
    Average 90 stars, based on 1 article reviews
    frozen human peripheral blood mononuclear cells (pbmcs) - by Bioz Stars, 2026-03
    90/100 stars

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    a diABZI-i inhibits cGAMP-induced IFNβ in <t>PBMCs</t> ( n = 3 | 1 donor) and diABZI-a1 induces IFNβ in PBMCs ( n = 3 | 3 donors, representative donor displayed). Data represented as mean with SD in graph. Source data are provided as a Source Data file. b Superposition of crystal structures (side view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). c diABZI-a1 and diABZI-i superposition over the STING binding pocket. d Cartoon depicting apical wing distance and beta sheet lid between STING monomers. e Superposition of crystal structures (top view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). f THIQi inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor). Data represented as mean with SD in graph. Source data are provided as a Source Data file. g Crystal structure overlay (top view) of STING bound to THIQi (orange) and diABZI-i (purple). h Apical wing distance measurements from structures in this study and reference structures collected from the PDB.
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    a diABZI-i inhibits cGAMP-induced IFNβ in <t>PBMCs</t> ( n = 3 | 1 donor) and diABZI-a1 induces IFNβ in PBMCs ( n = 3 | 3 donors, representative donor displayed). Data represented as mean with SD in graph. Source data are provided as a Source Data file. b Superposition of crystal structures (side view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). c diABZI-a1 and diABZI-i superposition over the STING binding pocket. d Cartoon depicting apical wing distance and beta sheet lid between STING monomers. e Superposition of crystal structures (top view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). f THIQi inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor). Data represented as mean with SD in graph. Source data are provided as a Source Data file. g Crystal structure overlay (top view) of STING bound to THIQi (orange) and diABZI-i (purple). h Apical wing distance measurements from structures in this study and reference structures collected from the PDB.
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    Average 90 stars, based on 1 article reviews
    frozen human peripheral blood mononuclear cells (pbmc) - by Bioz Stars, 2026-03
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    frozen peripheral blood cells (pbmcs)  (STEMCELL Technologies Inc)
    90
    STEMCELL Technologies Inc frozen peripheral blood cells (pbmcs)
    a diABZI-i inhibits cGAMP-induced IFNβ in <t>PBMCs</t> ( n = 3 | 1 donor) and diABZI-a1 induces IFNβ in PBMCs ( n = 3 | 3 donors, representative donor displayed). Data represented as mean with SD in graph. Source data are provided as a Source Data file. b Superposition of crystal structures (side view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). c diABZI-a1 and diABZI-i superposition over the STING binding pocket. d Cartoon depicting apical wing distance and beta sheet lid between STING monomers. e Superposition of crystal structures (top view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). f THIQi inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor). Data represented as mean with SD in graph. Source data are provided as a Source Data file. g Crystal structure overlay (top view) of STING bound to THIQi (orange) and diABZI-i (purple). h Apical wing distance measurements from structures in this study and reference structures collected from the PDB.
    Frozen Peripheral Blood Cells (Pbmcs), supplied by STEMCELL Technologies Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/frozen peripheral blood cells (pbmcs)/product/STEMCELL Technologies Inc
    Average 90 stars, based on 1 article reviews
    frozen peripheral blood cells (pbmcs) - by Bioz Stars, 2026-03
    90/100 stars
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    Image Search Results


    a diABZI-i inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor) and diABZI-a1 induces IFNβ in PBMCs ( n = 3 | 3 donors, representative donor displayed). Data represented as mean with SD in graph. Source data are provided as a Source Data file. b Superposition of crystal structures (side view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). c diABZI-a1 and diABZI-i superposition over the STING binding pocket. d Cartoon depicting apical wing distance and beta sheet lid between STING monomers. e Superposition of crystal structures (top view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). f THIQi inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor). Data represented as mean with SD in graph. Source data are provided as a Source Data file. g Crystal structure overlay (top view) of STING bound to THIQi (orange) and diABZI-i (purple). h Apical wing distance measurements from structures in this study and reference structures collected from the PDB.

    Journal: Nature Communications

    Article Title: Orthosteric STING inhibition elucidates molecular correction of SAVI STING

    doi: 10.1038/s41467-025-60632-5

    Figure Lengend Snippet: a diABZI-i inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor) and diABZI-a1 induces IFNβ in PBMCs ( n = 3 | 3 donors, representative donor displayed). Data represented as mean with SD in graph. Source data are provided as a Source Data file. b Superposition of crystal structures (side view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). c diABZI-a1 and diABZI-i superposition over the STING binding pocket. d Cartoon depicting apical wing distance and beta sheet lid between STING monomers. e Superposition of crystal structures (top view) of STING bound to diABZI-a1 (gray) and diABZI-i (purple). f THIQi inhibits cGAMP-induced IFNβ in PBMCs ( n = 3 | 1 donor). Data represented as mean with SD in graph. Source data are provided as a Source Data file. g Crystal structure overlay (top view) of STING bound to THIQi (orange) and diABZI-i (purple). h Apical wing distance measurements from structures in this study and reference structures collected from the PDB.

    Article Snippet: Frozen human peripheral blood mononuclear cells (PBMCs, BioIVT) are gently thawed, suspended in complete medium [AIMV, 10% heat-inactivated FBS, 1% antibiotic-antimycotic, 1% sodium pyruvate, 1% MEM non-essential amino acids; ThermoFisher] and concentrated by low-speed centrifugation (400 × g, ambient temperature, five minutes).

    Techniques: Binding Assay